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KMID : 0376219760130010059
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Chonnam Medical Journal
1976 Volume.13 No. 1 p.59 ~ p.68
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Experimental Studies of Extracorporeal Circulation by Rygg-kyvsgaard, Heart-Lung-Machine, Hartman´s Solution Prime, and Moderate Hypothermia on the Artificial Pneumothorax.
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Abstract
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Total body perfusion using Rygg-Kyvsgaard Heart-Lung-Machine, Mark IV, Polystan was attempted in the dog by the hemodilution method with total prime of buffered Hartman´s Solution and under hypothermia.
The first of all, the function of Rygg-Kyvsgaard Heart-Lung-Machine and the effect of the hemodilution perfusion by buffered Hartman´s solution was studied. At the same time the changes of blood pressure, oxygen consumption, and influence on the blood picture were observed before, during, arid in 1-3 days after perfusion.
Hemodilution rates were the average 74.22cc/kg(the range of 67 to 81cc/kg) and perfusion flow rates were maintained in the mean.62. 2 cc/kg/min., Although it was possible to check up to 87 cc/kg/min. The total body perfusion continued for 60-80 minutes. Hypothermia was employed between 36°C and of the rectal temperature.
Arterial pressure was range approximately between 6.5cm H20 and 11. 5cm H20. Optimum oxygenation can be expected when oxygen flow into the disposable bubble oxygenator was maintained approximately at 3.5L/min. In this way, the oxygen content were measured in the mean value of 13. 11±0. 56 vol. of arterial blood and .67+1.08 vol. % of venous blood (p<6,001). Under this condition, 4.78±0.86 vol, % in arteriovenous oxygen difference and 2.97 ±0. 62cc/kg in oxygen consumption were calculated.
According to these datas, it is as plain as pikestaff that excellent oxygenation and good tissue perfusion was accomplished.
Erythrocyte hemoglobin and Jhenlatocrit were :decreased.,about during extracorporeal circulation and these were not recovered until 1-3 days after perfusion. These decrease w-as resulted from relatively high degree of hemodilution rate and no blood transfusion to compensate during these experimentali studies. The platelets were iso ´decreased about fib% during perfusion, but on´ the contrary, it, was increased progressively after perfusion and in 1-3 days after perfusion was returned to the control level.
Leucocyte were also decreased during perfusion, but it was increased progressively after perfusion and in 1-3 days after perfusion exceed the control level. This increase was resulted from postoperative infection of the wound, but its analysis were not changed significantly.
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